Histone lactylation: epigenetic mark of glycolytic switch
X Dai, X Lv, EW Thompson, KK Ostrikov - Trends in Genetics, 2022 - cell.com
X Dai, X Lv, EW Thompson, KK Ostrikov
Trends in Genetics, 2022•cell.comHistone lactylation and acetylation compete for epigenetic modification of lysines and mark
the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA
generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking
control over the glycolytic switch as marked by lactylation suggests novel therapeutic
opportunities against cancers.
the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA
generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking
control over the glycolytic switch as marked by lactylation suggests novel therapeutic
opportunities against cancers.
Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel therapeutic opportunities against cancers.
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