[HTML][HTML] Peroxisomal L-bifunctional protein deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice
Background Proximal tubular (PT) cells are enriched in mitochondria and peroxisomes.
Whereas mitochondrial fatty acid oxidation (FAO) plays an important role in kidney function
by supporting the high-energy requirements of PT cells, the role of peroxisomal metabolism
remains largely unknown. L-bifunctional protein (EHHADH) catalyzes the second and third
step of peroxisomal FAO. Methods We studied kidneys of WT and Ehhadh KO mice on a
C57BL/6N background using histology, immunohistochemistry, immunofluorescence …
Whereas mitochondrial fatty acid oxidation (FAO) plays an important role in kidney function
by supporting the high-energy requirements of PT cells, the role of peroxisomal metabolism
remains largely unknown. L-bifunctional protein (EHHADH) catalyzes the second and third
step of peroxisomal FAO. Methods We studied kidneys of WT and Ehhadh KO mice on a
C57BL/6N background using histology, immunohistochemistry, immunofluorescence …