Programmed death-1 receptor negatively regulates LPS-mediated IL-12 production and differentiation of murine macrophage RAW264. 7 cells
HY Cho, EK Choi, SW Lee, KO Jung, SK Seo, IW Choi… - Immunology letters, 2009 - Elsevier
While programmed death-1 (PD-1), a co-inhibitory member of CD28 immunoglobulin
superfamily plays negative roles in effector functions of T cells and B cells, little is known
about the function of PD-1 expressed on innate immune cells. In this study, we demonstrate
that IL-12 production was greatly suppressed in LPS-stimulated RAW264. 7 cells upon PD-1
engagement with B7-H1. Fc fusion protein, and was restored in the presence of antagonistic
anti-PD-1 mAb. PD-1-mediated suppression of IL-12 production in LPS-stimulated RAW264 …
superfamily plays negative roles in effector functions of T cells and B cells, little is known
about the function of PD-1 expressed on innate immune cells. In this study, we demonstrate
that IL-12 production was greatly suppressed in LPS-stimulated RAW264. 7 cells upon PD-1
engagement with B7-H1. Fc fusion protein, and was restored in the presence of antagonistic
anti-PD-1 mAb. PD-1-mediated suppression of IL-12 production in LPS-stimulated RAW264 …
