The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling
H Zhong, H Yu, J Chen, SWF Mok, X Tan, B Zhao… - Vascular …, 2022 - Elsevier
Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate,
propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease.
Whether SCFAs regulate vascular calcification, a common pathological change in
cardiovascular tissues, remains unclear. This study aimed to investigate the potential role of
SCFAs in vascular calcification. Using cellular and animal models of vascular calcification,
we showed that butyrate significantly enhanced high phosphate (Pi)-induced calcification …
propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease.
Whether SCFAs regulate vascular calcification, a common pathological change in
cardiovascular tissues, remains unclear. This study aimed to investigate the potential role of
SCFAs in vascular calcification. Using cellular and animal models of vascular calcification,
we showed that butyrate significantly enhanced high phosphate (Pi)-induced calcification …
