Kynurenine as an Intermediate in the Formation of Nicotinic Acid from Tryptophane by Neurospora
GW Beadle, HK Mitchell, JF Nyc - Proceedings of the …, 1947 - National Acad Sciences
GW Beadle, HK Mitchell, JF Nyc
Proceedings of the National Academy of Sciences, 1947•National Acad SciencesFor a number of yearsit has been clear that nicotinic acid is synthesized by at least some
mamnials. The amount of this. vitamin retained in the body of a rat plus that excreted may far
exceed the dietary intake.'-'On a diet containing adequate protein the dog appears not to
need exogenous nicotinic acid. 4 Recently it has been show-n that nicotinic acid synthesis in
the rat, 3'5-man, 8 I the horse10 and the cotton rat'0 is increased when the diet is high in
tryptophane. It has likewise been shown by Woolley" and by Kodicek, Carpenter and Harris" …
mamnials. The amount of this. vitamin retained in the body of a rat plus that excreted may far
exceed the dietary intake.'-'On a diet containing adequate protein the dog appears not to
need exogenous nicotinic acid. 4 Recently it has been show-n that nicotinic acid synthesis in
the rat, 3'5-man, 8 I the horse10 and the cotton rat'0 is increased when the diet is high in
tryptophane. It has likewise been shown by Woolley" and by Kodicek, Carpenter and Harris" …
For a number of yearsit has been clear that nicotinic acid is synthesized by at least some mamnials. The amount of this. vitamin retained in the body of a rat plus that excreted may far exceed the dietary intake.'-'On a diet containing adequate protein the dog appears not to need exogenous nicotinic acid. 4 Recently it has been show-n that nicotinic acid synthesis in the rat, 3'5-man, 8 I the horse10 and the cotton rat'0 is increased when the diet is high in tryptophane.
It has likewise been shown by Woolley" and by Kodicek, Carpenter and Harris" 2 that nicotinic acid and tryptophane are interchangeable in coun-teracting the pellagragenic effects of 3-acetyl pyridine, indQle-3-acetic acid, and a factor present in corn that may be related to one of these. As pointed out by Rosen, Huff andPerlzweig5 these facts suggest that tryptophane may serve as natural precursor of nicotinic acid. Other interpretations are possible, however."
National Acad Sciences
