[HTML][HTML] Kennedy's disease: Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its clevage by caspase-3 and enhances cell death
MA LaFevre-Bernt, LM Ellerby - Journal of Biological Chemistry, 2003 - ASBMB
X-linked spinal and bulbar muscular atrophy is a degenerative disease affecting motor
neurons that is caused by polyglutamine (polyQ) expansion within the androgen receptor
(AR). The polyQ-expanded form of AR is cytotoxic to cells, and proteolytic cleavage
enhances cell death. The intracellular signaling pathways activated and/or required for cell
death induced by the expanded form of AR (AR112) are unknown. We found that AR
regulates mitogen-activated protein kinase (MAP kinase) pathways and, therefore …
neurons that is caused by polyglutamine (polyQ) expansion within the androgen receptor
(AR). The polyQ-expanded form of AR is cytotoxic to cells, and proteolytic cleavage
enhances cell death. The intracellular signaling pathways activated and/or required for cell
death induced by the expanded form of AR (AR112) are unknown. We found that AR
regulates mitogen-activated protein kinase (MAP kinase) pathways and, therefore …
