Cell-derived decellularized extracellular matrices
GM Harris, I Raitman, JE Schwarzbauer - Methods in Cell Biology, 2018 - Elsevier
The ability to create cell-derived decellularized matrices in a dish gives researchers the
opportunity to possess a bioactive, biocompatible material made up of fibrillar proteins and
other factors that recapitulates key features of the native structure and composition of in vivo
microenvironments. By using cells in a culture system to provide a natural ECM,
decellularization allows for a high degree of customization through the introduction of
selected proteins and soluble factors. The culture system, culture medium, cell types, and …
opportunity to possess a bioactive, biocompatible material made up of fibrillar proteins and
other factors that recapitulates key features of the native structure and composition of in vivo
microenvironments. By using cells in a culture system to provide a natural ECM,
decellularization allows for a high degree of customization through the introduction of
selected proteins and soluble factors. The culture system, culture medium, cell types, and …
